BurnPitsExposure

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    ClinicalKeyTopics(Beta)

    The latest evidence-based research from ClinicalKey

    Many veterans and service members who served in Iraq, Afghanistan, and other locations were exposed to toxic burn pits, leading to serious health problems, such as respiratory diseases, cancers, cardiovascular disorders, and neurological conditions. To help ClinicalKey users stay current on this emerging health issue, we created this topic page with the most relevant journal articles and clinical overviews from ClinicalKey.

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    Featured Article

    Military burn pit exposure and airway disease

    Annals of Allergy, Asthma & Immunology | December 1, 2023

    The text discusses the potential health risks associated with exposure to burn pit smoke for veterans. It highlights the toxic compounds present in the fumes that can cause or worsen airway diseases. The Veterans Administration has established a registry to track the health of those exposed to burn pit smoke, but proving causality between burn pit exposure and airway disease has been difficult. The article reviews current research on the potential impact of burn pit exposure on chronic airway disease.

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    Window of opportunity for respiratory oscillometry: A review of recent research

    Respiratory Physiology & Neurobiology

    Oct 1, 2023

    The Forced Oscillation Technique (FOT), performed during tidal breathing, is free from patient-dependent factors that may influence the results. Different lung diseases show different patterns of change in FOT...

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    Environmental and occupational bronchiolitis obliterans: new reality

    eBioMedicine

    Sept 1, 2023

    Environmental/occupational bronchiolitis obliterans often present with an indolent evolution of respiratory symptoms without a history of high-level, acute exposure to airborne toxins. Exertional dyspnea is the most common symptom...

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    Caring for Veterans with Serious Illness

    Clinics in Geriatric Medicine

    Aug 1, 2023

    US Veterans comprise approximately 7% of the population. About half of these Veterans seek care within the Department of Veterans Affairs. The other half receive their health-care services in the wider community...

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    Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis

    Rheumatic Disease Clinics of North America

    Nov 1, 2022

    Rheumatoid arthritis (RA) occurs as the result of a complex interplay of environmental factors in a genetically susceptible individual. There is considerable evidence that the lungs may serve as an initial site of tolerance loss in the generation of RA...

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    Mosaic Attenuation Pattern

    American Journal of Obstetrics and Gynecology

    Nov 1, 2022

    The mosaic attenuation pattern can be seen on high-resolution computed tomography and has various causes, including small airways disease and vascular causes. Ancillary CT findings and clinical history help to narrow the differential diagnosis...

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    Lifetime infertility and environmental, chemical, and hazardous exposures among female and male US veterans

    American Journal of Obstetrics and Gynecology

    Nov 1, 2022

    A study has found that infertility in veterans is associated with exposure to environmental, chemical, and hazardous materials during military service. The study surveyed 3,018 veterans, of whom 49.6% of women and 51.7% of men met the definition of...

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    1. Self-reported respiratory outcomes associated with blast exposure in post 9/11 veterans
      Respiratory Medicine2 de octubre de 2022Source: ClinicalKey

      Blast exposure independently predicts presence of cough, wheeze, and dyspnea. Blast-exposed veterans were more likely to report respiratory symptoms than unexposed veterans. Care for injury at Landstuhl was inversely associated with reporting of all symptoms and all diagnoses.

    2. Small airways and airspace inflammation and injury distinguish lung histopathology in deployed military personnel from healthy and diseased lungs
      Human Pathology2 de junio de 2022Source: ClinicalKey

      Military deployment to Iraq and Afghanistan increases the risk for lung disease, according to a new study. Biopsies of symptomatic deployers were compared to diseased and normal controls, and a novel semiquantitative electronic histologic scoring system was used. Findings in deployers overlapped most with chronic hypersensitivity pneumonitis, and abnormalities were more common in the lower lobe than upper lobe biopsies. The study found that several deployers had bronchiolitis, though this finding was substantially less frequent than in OB cases, and moderate/severe emphysema was noted in 46.2% of symptomatic deployers, of whom nearly half (46.7%) were never smokers.

    3. Military exposures and lung cancer in United States Veterans
      Seminars in Oncology2 de junio de 2022Source: ClinicalKey

      Lung cancer screening begins at age 50, with yearly low dose computed tomography (LDCT) scans until age 80. Veterans serving from World War II to the Gulf War are now at the age where LDCT is recommended. The additional risk of lung cancer due to military exposure history is unclear.

    4. Controversies and challenges in lung cancer screening
      Seminars in Oncology2 de junio de 2022Source: ClinicalKey

      Two large randomized controlled trials have shown mortality benefit from lung cancer screening (LCS) in high-risk groups. Updated guidelines by the United State Preventative Service Task Force in 2020 will allow for inclusion of more patients who are at high risk of developing lung cancer and benefit from screening. The advantage of LDCT is its high sensitivity for detecting pulmonary nodules while using approximately five times less radiation compared with conventional CT.

    5. Sustained Club Cell Injury in Mice Induces Histopathologic Features of Deployment-Related Constrictive Bronchiolitis
      American Journal of Pathology, The2 de marzo de 2022Source: ClinicalKey

      The study investigates the pathogenesis of Deployment-Related Constrictive Bronchiolitis (DRCB) in soldiers deployed to Southwest Asia. The study found that sustained club cell injury in mice led to chronic peribronchiolar fibrosis and the accumulation of alternatively activated macrophages. The study also found that alveolar macrophages contribute to the development of CB and that depletion of alveolar macrophages in mice ameliorated CB. The study suggests that sustained club cell injury is implicated in the development of DRCB and provides potential biomarkers and treatment targets for the disorder.

    6. The Millennium Cohort Study: The first 20 years of research dedicated to understanding the long-term health of US Service Members and Veterans
      Annals of Epidemiology2 de marzo de 2022Source: ClinicalKey

      The Study will continue to foster stakeholder relationships such that research findings inform and guide policy initiatives and health promotion efforts. Summarize: Conclusions. Summaries: Findings will inform policy initiatives. Conclusions: Research findings will guide and inform policy efforts and efforts to improve health.

    Toxicities, Poisonings, and Overdoses

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