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Careplan

Sepsis or Septic Shock (Adult Inpatient)

Mar.16.2022

Sepsis/Septic Shock (Adult Inpatient)

Clinical Description

  • Care of the hospitalized patient experiencing life-threatening organ dysfunction caused by a dysregulated response to infection.

Key Information

  • Outcomes are improved by early identification of sepsis and the immediate initiation of evidence-based therapy following sepsis recognition, including aggressive fluid resuscitation and antimicrobial therapy.
  • Positive pressure ventilation and sedation may lead to profound hemodynamic instability prior to adequate fluid resuscitation.
  • Avoid medications, such as aspirin and nonsteroidal anti-inflammatory agents, that interfere with platelet function for patients who are at risk for developing DIC (disseminated intravascular coagulation).

Clinical Goals

By transition of care

A. The patient will achieve the following goals:
  • Optimal Coping

  • Absence of Bleeding

  • Blood Glucose Level Within Targeted Range

  • Absence of Infection Signs and Symptoms

  • Optimal Nutrition Delivery

B. Patient, family or significant other will teach back or demonstrate education topics and points:
  • Education: Overview
  • Education: Self-Management
  • Education: When to Seek Medical Attention

Correlate Health Status

  • Correlate health status to:

    • history, comorbidity
    • age, developmental level
    • sex, gender identity
    • baseline assessment data
    • physiologic status
    • response to medication and interventions
    • psychosocial status, social determinants of health
    • barriers to accessing care and services
    • health literacy
    • cultural and spiritual preferences
    • safety risks
    • family interaction
    • plan for transition of care

Adjustment to Illness

Signs/Symptoms/Presentation

  • anxiety
  • apprehension
  • concern
  • distress
  • fear
  • feeling overwhelmed
  • grief
  • guilt
  • helplessness
  • loss of control
  • powerlessness
  • self-blame
  • uncertainty
  • vulnerability
  • worry

Problem Intervention

Optimize Psychosocial Adjustment to Illness

  • Acknowledge, normalize, validate intensity and complexity of patient and support system response to situation.
  • Provide opportunity for expression of thoughts, feelings and concerns; respond with compassion and reassurance.
  • Decrease stress and anxiety by providing information about patient’s status and treatment.
  • Facilitate support system presence and participation in care; consider providing a diary in intensive care situation.
  • Support coping by recognizing current coping strategies; provide aid in developing new strategies.
  • Acknowledge and normalize concerns about potential lifestyle changes and expectations.
  • Assess and monitor for signs and symptoms of psychologic distress, anxiety and depression.
  • Consider palliative care consult for goals of care conversation, if the condition is worsening despite treatment.

Associated Documentation

  • Family/Support System Care
  • Supportive Measures

Bleeding

Signs/Symptoms/Presentation

  • bleeding noted from intravenous sites, gums, wound
  • bruising (ecchymosis)
  • capillary refill delayed
  • hematuria
  • mental status change
  • peripheral pulse strength decreased
  • petechiae
  • purpuric rash
  • skin mottled

Vital Signs

  • heart rate increased or decreased
  • respiratory rate increased
  • blood pressure increased or decreased

Laboratory Values

  • coagulation studies abnormal
  • FDP (fibrin degradation products) increased
  • fibrinogen abnormal
  • Hct (Hematocrit) decreased
  • Hgb (Hemoglobin) decreased
  • platelet count low
  • positive D-dimer level
  • RBC (red blood cell count) decreased

Hemodynamic Values

  • cardiac index decreased
  • cardiac output decreased
  • CVP (central venous pressure) decreased
  • MAP (mean arterial pressure) decreased

Problem Intervention

Monitor and Manage Bleeding

  • Maintain bleeding precautions; provide safe environment and gentle care activities, such as positioning, oral and skin care.
  • Avoid invasive procedures and medication that increase risk of bleeding; monitor for signs of bleeding frequently.
  • Consider need for fluid volume replacement (e.g., intravenous fluid, blood products) to maintain perfusion.
  • Consider adjunctive supportive therapy, such as platelet infusion or heparin.
  • Provide protective hemostasis by applying direct pressure to a visible bleeding site.

Associated Documentation

  • Bleeding Management
  • Bleeding Precautions

Glycemic Control Impaired

Laboratory Values

  • blood glucose level outside desired range

Problem Intervention

Optimize Glycemic Control

  • Establish target blood glucose levels based on patient-specific factors, such as illness severity and comorbidity.
  • Document blood glucose levels and monitor trend.
  • If elevated blood glucose level is not within desired range, initiate insulin therapy using an insulin management protocol.
  • Avoid hypoglycemic episodes by proactively adjusting insulin therapy if there is a change in condition, treatment, illness severity, medication or nutrition support therapy.

Associated Documentation

  • Glycemic Management

Infection Progression

Signs/Symptoms/Presentation

  • breath sounds abnormal
  • breathing pattern ineffective
  • capillary refill delayed
  • confusion
  • diaphoresis
  • fluid balance change
  • heart sounds abnormal
  • level of consciousness decreased
  • mental status change
  • peripheral pulses decreased or absent
  • perfusion altered
  • shortness of breath
  • skin mottled
  • skin temperature change
  • sputum characteristic change
  • stool characteristic change
  • urine characteristic change
  • urine output decreased
  • work of breathing increased

Vital Signs

  • heart rate increased
  • respiratory rate increased
  • blood pressure increased or decreased
  • SpO2 (peripheral oxygen saturation) decreased
  • EtCO2 (end-tidal carbon dioxide) increased
  • temperature increased or decreased

Laboratory Results

  • ABG (arterial blood gas) abnormal
  • blood glucose level increased
  • CBC (complete blood count) with differential abnormal
  • coagulation studies abnormal
  • CRP (C-reactive protein) increased
  • CSF (cerebrospinal fluid) evaluation abnormal
  • culture positive (urine, wound, blood)
  • Hct (Hematocrit) decreased
  • Hgb (Hemoglobin) decreased
  • ionized calcium level abnormal
  • procalcitonin level increased
  • serum bilirubin increased
  • serum creatinine increased
  • serum electrolytes abnormal
  • serum lactate increased
  • ScvO2 (central venous oxygen saturation) decreased
  • SvO2 (mixed venous oxygen saturation) decreased
  • WBC (white blood cell) count change

Diagnostic Results

  • ECHO (echocardiography) abnormal
  • radiologic evaluation abnormal

Hemodynamic Values

  • CI (cardiac index) decreased
  • CO (cardiac output) decreased
  • CVP (central venous pressure) decreased
  • MAP (mean arterial pressure) decreased
  • SV (stroke volume) decreased
  • SVR (systemic vascular resistance) increased or decreased

Problem Intervention

Initiate Sepsis Management

  • Provide fluid therapy, such as crystalloid or albumin, to increase intravascular volume, organ perfusion and oxygen delivery.
  • Provide respiratory support, such as oxygen therapy, noninvasive or invasive positive pressure ventilation, to achieve oxygenation and ventilation goal; avoid hyperoxemia.
  • Obtain cultures prior to initiating antimicrobial therapy when possible. Do not delay for laboratory results in the presence of high suspicion or clinical indicators.
  • Administer intravenous broad-spectrum antimicrobial therapy promptly.
  • Implement hemodynamic monitoring to guide intravascular support based on individual targeted parameters.
  • Determine and address underlying source of infection aggressively; implement transmission-based precautions and isolation, as indicated.

Associated Documentation

  • Infection Management
  • Infection Prevention
  • Isolation Precautions
  • Stabilization Measures

Problem Intervention

Promote Stabilization

  • Monitor for signs of fluid responsiveness and overload; consider fluid adjustment and diuretic therapy.
  • Anticipate use of vasoactive agent to support microperfusion and oxygen delivery; titrate to response.
  • Monitor laboratory value, diagnostic test and clinical status trends for signs of infection progression and multiple organ failure.
  • Assess effectiveness of, and potential for, de-escalation of the antimicrobial regimen daily.
  • Provide fever-reduction and comfort measures.
  • Monitor and manage electrolyte imbalance, such as hypocalcemia.
  • Use lung protective ventilation measures, such as low volume, inspiratory pressure, optimal positive end-expiratory pressure, to minimize the risk of ventilator-induced lung injury; ensure minute volume demands.
  • Prepare for supportive therapy, such as prone positioning, corticosteroid therapy, coagulopathy management, CRRT (continuous renal replacement therapy), hemofiltration and cardiac-assist device.

Associated Documentation

  • Fever Reduction/Comfort Measures
  • Fluid/Electrolyte Management
  • Lung Protection Measures

Problem Intervention

Promote Recovery

  • Encourage pulmonary hygiene, such as cough-enhancement and airway-clearance techniques, that may include use of incentive spirometry, deep breathing and cough.
  • Encourage early rehabilitation and physical activity to optimize functional ability and activity tolerance, as well as minimize delirium.
  • Promote energy conservation; minimize oxygen demand and consumption by adjusting environment, decreasing stimulation, maintaining normothermia and treating pain.
  • Optimize fluid balance, nutrition intake, sleep and glycemic control to maintain tissue perfusion and enhance immune response.

Associated Documentation

  • Activity Management
  • Airway/Ventilation Support
  • Sleep/Rest Enhancement

Nutrition Impaired

Signs/Symptoms/Presentation

  • inability to take in adequate oral intake

Problem Intervention

Promote and Optimize Nutrition Delivery

  • Perform a nutritional assessment; include a nutrition-focused physical exam.
  • Determine calorie, protein, vitamin, mineral and fluid requirements.
  • Initiate early enteral nutrition support; enteral is preferred over parenteral due to physiologic benefits, such as maintenance of gut integrity and function, reduction of infection risk and provision of stress ulcer prophylaxis.
  • Optimize protein intake, unless contraindicated.
  • Assess for micronutrient deficiencies; supplement if depleted.
  • Consider postpyloric versus gastric tube feeding for patient at increased risk of aspiration.
  • Advocate for and adjust infusion rate, formulation or volume based on feeding tolerance and clinical status (e.g., hemodynamic stability); minimize unnecessary interruptions.
  • Anticipate the need for a promotility agent if reduced gastric emptying or delayed bowel motility is suspected.
  • Monitor nutrition delivery to ensure safe practices (e.g., confirmation of tube placement, tube patency, medication delivery, head of bed elevation, oral care).

Associated Documentation

  • Nutrition Support Management

Education

CPG-Specific Education Topics

Overview

  • description

  • signs/symptoms

Self-Management

  • activity

  • fluid/food intake

  • immunizations

  • infection prevention

  • postsepsis syndrome

  • provider follow-up

  • VTE prevention

When to Seek Medical Attention

  • unresolved/worsening symptoms

  • VTE symptoms

General Education Topics

General Education

  • admission, transition of care

  • orientation to care setting, routine

  • advance care planning

  • diagnostic tests/procedures

  • diet modification

  • opioid medication management

  • oral health

  • medication management

  • pain assessment process

  • safe medication disposal

  • tobacco use, smoke exposure

  • treatment plan

Safety Education

  • call light use

  • equipment/home supplies

  • fall prevention

  • harm prevention

  • infection prevention

  • MDRO (multidrug-resistant organism) care

  • personal health information

  • resources for support

Population-Specific Considerations

Geriatric

  • A change in mental status may be the first or only symptom of infection in older adults.

Quality Measures

  • NQF 0500: Severe Sepsis and Septic Shock: Management Bundle
    This measure focuses on adults 18 years and older with a diagnosis of severe sepsis or septic shock. Consistent with Surviving Sepsis Campaign guidelines, the measure contains several elements, including measurement of lactate, obtaining blood cultures, administering broad spectrum antibiotics, fluid resuscitation, vasopressor administration, reassessment of volume status and tissue perfusion, and repeat lactate measurement. As reflected in the data elements and their definitions, these elements should be performed in the early management of severe sepsis and septic shock.
    Steward: Henry Ford Hospital
    Care Setting: Hospital
    National Quality Forum-endorsed measure
    Last Edited: 07/13/2017

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Disclaimer

Clinical Practice Guidelines represent a consistent/standardized approach to the care of patients with specific diagnoses. Care should always be individualized by adding patient specific information to the Plan of Care.

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