Antithrombin III Injection

ANTITHROMBIN III (an tee THRAAM bin three) prevents and treats blood clots. It works by replacing the antithrombin normally made by the body. Antithrombin is a protein that prevents blood from clotting too much.

This medication is infused into a vein. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. Special care may be needed.

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Change in taste
• Dizziness
• Muscle pain or cramps
• Nausea

This medication is given in a hospital or clinic. It will not be stored at home.

They need to know if you have any of these conditions:

• An unusual or allergic reaction to antithrombin III, goat or goat milk proteins, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

Do not take this medication with any of the following:

• Defibrotide

This medication may also interact with the following:

• Medications that prevent or treat blood clots, such as heparin
• Mifepristone

This does not apply.

Your condition will be monitored carefully while you are receiving this medication.

You may need blood work done while you are taking this medication.

This medication is made from donated human blood. There is a small risk that they may contain bacteria or viruses, such as hepatitis or HIV. All products are processed to kill most bacteria and viruses. Talk to your care team if you have questions about the risk of infection.

Avoid sports and activities that may cause injury while you are taking this medication. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your care team.

If you are going to need surgery or a procedure, tell your care team that you are taking this medication.

Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.