ANTITHROMBIN III (AN te throm bin) is a natural protein. It is used to treat patients with low levels of antithrombin III. People with this condition may have an increased risk for developing blood clots, especially during surgery or during pregnancy. This medicine may help to reduce the risk for blood clots or help to treat blood clots once they have already developed.

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
• signs and symptoms of a blood clot such as chest pain; shortness of breath; pain, swelling, or warmth in the leg
• signs and symptoms of a stroke such as changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking; dizziness; loss of coordination

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• dizziness
• pain, redness or irritation at site where injected

This drug is given in a hospital or clinic and will not be stored at home.

They need to know if you have any of these conditions:

•an unusual or allergic reaction to antithrombin III, goat or goat milk proteins, other medicines, foods, dyes, or preservatives

•pregnant or trying to get pregnant

•breast-feeding

Do not take this medicine with any of the following medications:

•aspirin and aspirin-like drugs

•medicines that treat or prevent blood clots like warfarin or heparin

•mifepristone

This does not apply.

Visit your healthcare professional for regular checks on your progress. You may need blood work done while you are taking this medicine. Your condition will be monitored carefully while you are receiving this medicine. It is important not to miss any appointments.

Avoid sports and activities that might cause injury while you are using this medicine. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your healthcare professional.

If you are going to need surgery or other procedure, tell your healthcare professional that you are using this medicine.