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Complications and Prognosis
Bleeding complications or severe anemia requiring inpatient treatment or monitoring
Infection requiring IV antibiotics or inpatient monitoring
Management for all patients diagnosed with aplastic anemia
Further treatment will depend on severity of illness, patient age, and need for transfusion
Allogeneic stem cell transplantation from an HLA-matched sibling donor is curative in over 90% of children and 80% of adolescents and does not require prior irradiation r6
Well-matched alternative donor stem cells may achieve a good result but with a higher risk of graft-versus-host disease; prior irradiation decreases risk of graft-versus-host disease r3r44
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