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Canagliflozin Oral tablet

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Canagliflozin Oral tablet

What is this medication?

CANAGLIFLOZIN (KAN a gli FLOE zin) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise. This drug may also reduce the risk of heart attack, stroke, or death if you have type 2 diabetes and risk factors for heart disease. If you have diabetic kidney disease with a certain amount of protein in the urine, this drug may reduce your risk of end stage kidney disease (ESKD), worsened kidney function, and hospitalization for heart failure.


This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

How should I use this medication?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take it before the first meal of the day. Take your dose at the same time each day. Do not take more often than directed. Do not stop taking except on your doctor's advice.


A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.


Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.


Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • chest pain
  • dizziness
  • feeling faint or lightheaded, falls
  • muscle weakness
  • nausea, vomiting, unusual stomach upset or pain
  • new pain or tenderness, change in skin color, sores or ulcers, or infection in legs or feet
  • penile discharge, itching, or pain in men
  • signs and symptoms of a genital infection, such as fever; tenderness, redness, or swelling in the genitals or area from the genitals to the back of the rectum
  • signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness
  • signs and symptoms of a urinary tract infection, such as fever, chills, a burning feeling when urinating, blood in the urine, back pain
  • tingling or numbness in the hands, legs, or feet
  • trouble passing urine or change in the amount of urine, including an urgent need to urinate more often, in larger amounts, or at night
  • unusual tiredness
  • vaginal discharge, itching, or odor in women


Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • mild increase in urination
  • thirsty


This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • artery disease
  • dehydration
  • diabetic ketoacidosis
  • diet low in salt
  • eating less due to illness, surgery, dieting, or any other reason
  • foot sores
  • having surgery
  • high cholesterol
  • high levels of potassium in the blood
  • history of amputation
  • history of pancreatitis or pancreas problems
  • history of yeast infection of the penis or vagina
  • if you often drink alcohol
  • infections in the bladder, kidneys, or urinary tract
  • kidney disease
  • liver disease
  • low blood pressure
  • nerve damage
  • on hemodialysis
  • problems urinating
  • type 1 diabetes
  • uncircumcised male
  • an unusual or allergic reaction to canagliflozin, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

What may interact with this medication?

Do not take this medicine with any of the following medications:

  • gatifloxacin


This medicine may also interact with the following medications:

  • alcohol
  • certain medicines for blood pressure, heart disease
  • digoxin
  • diuretics
  • insulin
  • nateglinide
  • phenobarbital
  • phenytoin
  • repaglinide
  • rifampin
  • ritonavir
  • sulfonylureas like glimepiride, glipizide, glyburide
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medication?

Visit your doctor or health care professional for regular checks on your progress.


This medicine can cause a serious condition in which there is too much acid in the blood. If you develop nausea, vomiting, stomach pain, unusual tiredness, or breathing problems, stop taking this medicine and call your doctor right away. If possible, use a ketone dipstick to check for ketones in your urine.


A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.


Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.


Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.


Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.


Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.


Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.