Dexamethasone Injection

DEXAMETHASONE (dex a METH a sone) treats many conditions such as asthma, allergic reactions, arthritis, inflammatory bowel diseases, adrenal, and blood or bone marrow disorders. It works by decreasing inflammation and slowing down an overactive immune system. It belongs to a group of medications called steroids.

This medication is injected into a muscle, joint, lesion, or other tissue. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. Special care may be needed.

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Cushing syndrome—increased fat around the midsection, upper back, neck, or face, pink or purple stretch marks on the skin, thinning, fragile skin that easily bruises, unexpected hair growth
• High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
• Increase in blood pressure
• Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
• Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
• Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
• Stomach bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds
• Swelling of the ankles, hands, or feet

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Acne
• General discomfort and fatigue
• Headache
• Increase in appetite
• Nausea
• Trouble sleeping
• Weight gain

This medication is given in a hospital or clinic. It will not be stored at home.

They need to know if you have any of these conditions:

• Cushing syndrome
• Diabetes
• Glaucoma
• Heart attack
• Heart disease
• High blood pressure
• Infection, such as tuberculosis (TB), bacterial, fungal, or viral infections
• Kidney disease
• Liver disease
• Mental health condition
• Myasthenia gravis
• Osteoporosis
• Seizures
• Stomach or intestine problems
• Thyroid disease
• An unusual or allergic reaction to dexamethasone, lactose, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

Do not take this medication with any of the following:

• Live virus vaccines

This medication may also interact with the following:

• Aminoglutethimide
• Amphotericin B
• Aspirin and aspirin-like medications
• Certain antibiotics, such as erythromycin, clarithromycin, troleandomycin
• Certain antivirals for HIV or hepatitis
• Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
• Certain medications to treat myasthenia gravis
• Cholestyramine
• Cyclosporine
• Digoxin
• Diuretics
• Ephedrine
• Estrogen and progestin hormones
• Insulin or other medications for diabetes
• Isoniazid
• Ketoconazole
• Medications that relax muscles for surgery
• Mifepristone
• NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
• Rifampin
• Skin tests for allergies
• Thalidomide
• Vaccines
• Warfarin

This does not apply.

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. Your condition will be monitored carefully while you are receiving this medication.

Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.

This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick. If you have not had the measles or chickenpox vaccines, tell your care team right away if you are around someone with these viruses.

If you are going to need surgery or other procedure, tell your care team that you are using this medication.

You may need to be on a special diet while you are taking this medication. Ask your care team. Also, find out how many glasses of fluids you need to drink each day.

This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.