Epoetin Alfa Injection

EPOETIN ALFA (e POE e tin AL fa) treats low levels of red blood cells (anemia) caused by kidney disease, chemotherapy, or HIV medications. It can also be used in people who are at risk for blood loss during surgery. It works by helping your body make more red blood cells, which reduces the need for blood transfusions.

This medication is injected into a vein or under the skin. It is usually given by your care team in a hospital or clinic setting. It may also be given at home.

If you get this medication at home, you will be taught how to prepare and give it. Use exactly as directed. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
• Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
• Increase in blood pressure
• Rash, fever, and swollen lymph nodes
• Redness, blistering, peeling, or loosening of the skin, including inside the mouth
• Seizures
• Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Bone, joint, or muscle pain
• Cough
• Headache
• Nausea
• Pain, redness, or irritation at injection site

Keep out of the reach of children and pets.

Store in a refrigerator. Do not freeze. Do not shake. Protect from light. Keep this medication in the original container until you are ready to take it. See product for storage information. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, ask your pharmacist or care team how to get rid of the medication safely.

They need to know if you have any of these conditions:

• Blood clots
• Cancer
• Heart disease
• High blood pressure
• On dialysis
• Seizures
• Stroke
• An unusual or allergic reaction to epoetin alfa, albumin, benzyl alcohol, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

• Darbepoetin alfa
• Methoxy polyethylene glycol-epoetin beta

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team. Your condition will be monitored carefully while you are receiving this medication.

You may need blood work while taking this medication.