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Histrelin Implant

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Feb.27.2023

Histrelin Implant

What is this medication?

HISTRELIN (his TREL in) treats a condition that causes early puberty. It works by decreasing levels of the hormones estrogen and testosterone in the body. This slows or stops signs of puberty while you are taking this medication.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

How should I use this medication?

This medication is placed under the skin of your arm by your care team in a clinic or office. After the implant is placed, keep the insertion site clean and dry for 24 hours. Avoid heavy lifting and strenuous exercise for 7 days after implant insertion. The surgical strips over the site should be allowed to fall off on their own over several days. The implant must be removed after 12 months. At this time, a new implant may be inserted to continue therapy.

A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While this drug may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting
Mood swings, irritability, hostility
Seizures

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

Pain, redness, or irritation at injection site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

Brain cancer or tumor
Mental health condition
Seizures
An unusual or allergic reaction to histrelin, other medications, foods, dyes, or preservatives
Pregnant or trying to get pregnant
Breast-feeding

What may interact with this medication?

Certain medications for depression, anxiety, or other mental health conditions
Estrogen or progestin hormones
Supplements, such as black cohosh or DHEA
Male hormones, like testosterone
Prasterone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What if I miss a dose?

This does not apply. After 1 year, the implant will have to be removed. If you need to continue this medication, the implant will be replaced at that time.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. During the first few weeks, the symptoms of puberty may get worse, but then will start to get better as treatment is continued. Check with your care team if they do not start to get better after several weeks.

Rarely, the implant can be expelled from the body through the original incision site. You may notice the implant being expelled, or rarely, the implant may be expelled without your noticing it. If you believe the implant has been expelled from your body, call your care team.