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Mild to moderate disease
Severe disease
Relapse prevention r25
Esketamine nasal spray—the first NMDA (N-methyl-D-aspartate) receptor antagonist to receive FDA approval for major depression—can be used as an adjunct to an oral antidepressant for treatment-resistant depression (those whose condition has failed to respond to 2 or more standard antidepressant treatments) r28r29
Music therapy