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Mar.31.2021

Oxycodone Hydrochloride Oral capsule

What is this medicine?

OXYCODONE (ox i KOE done) is a pain reliever, also called an opioid. It treats severe pain.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

How should I use this medicine?

Take this medicine by mouth with water. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your health care provider tells you to stop.

Some brands of this medicine, like Oxaydo, have special instructions. Ask your doctor or pharmacist if these directions are for you: Do not cut, crush or chew this medicine. Do not wet, soak, or lick the tablet before you take it.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions (skin rash, itching or hives; swelling of the face, lips, or tongue)
  • confusion
  • kidney injury (trouble passing urine or change in the amount of urine)
  • low adrenal gland function (nausea; vomiting; loss of appetite; unusually weak or tired; dizziness; low blood pressure)
  • low blood pressure (dizziness; feeling faint or lightheaded, falls; unusually weak or tired)
  • serotonin syndrome (irritable; confusion; diarrhea; fast or irregular heartbeat; muscle twitching; stiff muscles; trouble walking; sweating; high fever; seizures; chills; vomiting)
  • trouble breathing

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation
  • dry mouth
  • nausea, vomiting
  • tiredness
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children and pets. This medicine can be abused. Keep it in a safe place to protect it from theft. Do not share it with anyone. It is only for you. Selling or giving away this medicine is dangerous and against the law.

Store at 25 degrees C (77 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medicine after the expiration date.

This medicine may cause harm and death if it is taken by other adults, children, or pets. It is important to get rid of the medicine as soon as you no longer need it or it is expired. You can do this in two ways:

  • Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medicine, flush it down the toilet.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • brain tumor
  • drug abuse or addiction
  • head injury
  • heart disease
  • if you often drink alcohol
  • kidney disease
  • liver disease
  • low adrenal gland function
  • lung disease, asthma, or breathing problem
  • seizures
  • stomach or intestine problems
  • taken an MAOI such as Marplan, Nardil, or Parnate in the last 14 days
  • an unusual or allergic reaction to oxycodone, other drugs, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • safinamide

This medicine may interact with the following medications:

  • alcohol
  • antihistamines for allergy, cough, and cold
  • atropine
  • certain antivirals for HIV or hepatitis
  • certain antibiotics like clarithromycin, erythromycin, linezolid, rifampin
  • certain medicines for anxiety or sleep
  • certain medicines for bladder problems like oxybutynin, tolterodine
  • certain medicines for depression like amitriptyline, fluoxetine, sertraline
  • certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole
  • certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • certain medicines for nausea or vomiting like dolasetron, granisetron, ondansetron, palonosetron
  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, primidone
  • certain medicines for stomach problems like dicyclomine, hyoscyamine
  • certain medicines for travel sickness like scopolamine
  • diuretics
  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol
  • ipratropium
  • MAOIs like Marplan, Nardil, and Parnate
  • medicines that relax muscles
  • methylene blue
  • other narcotic medicines for pain or cough
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Tell your health care provider if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to this medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take this medicine for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a medicine for a nonmedical reason. If you have pain, you have a medical reason to take pain medicine. Your health care provider will tell you how much medicine to take. If your health care provider wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

If you take other medicines that also cause drowsiness such as other narcotic pain medicines, benzodiazepines, or other medicines for sleep, you may have more side effects. Give your health care provider a list of all medicines you use. He or she will tell you how much medicine to take. Do not take more medicine than directed. Get emergency help right away if you have trouble breathing or are unusually tired or sleepy.

Talk to your health care provider about naloxone and how to get it. Naloxone is an emergency medicine used for an opioid overdose. An overdose can happen if you take too much opioid. It can also happen if an opioid is taken with some other medicines or substances, such as alcohol. Know the symptoms of an overdose, such as trouble breathing, unusually tired or sleepy, or not being able to respond or wake up. Make sure to tell caregivers and close contacts where it is stored. Make sure they know how to use it. After naloxone is given, you must get emergency help right away. Naloxone is a temporary treatment. Repeat doses may be needed.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine will cause constipation. If you do not have a bowel movement for 3 days, call your health care provider.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your health care provider if the problem does not go away or is severe.

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