Oxycodone tablets or capsules

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    Oxycodone Hydrochloride Oral capsule

    What is this medication?

    OXYCODONE (ox i KOE done) treats severe pain. It is prescribed when other pain medications do not work well enough or cannot be tolerated. It works by blocking pain signals in the brain. It belongs to a group of medications called opioids.

    This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

    How should I use this medication?

    Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

    Some brands of this medication, like Oxaydo, have special instructions. Ask your care team or pharmacist if these directions are for you: Do not cut, crush or chew this medication. Do not wet, soak, or lick the tablet before you take it.

    A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

    Talk to your care team regarding the use of this medication in children. Special care may be needed.

    Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

    What side effects may I notice from receiving this medication?

    Side effects that you should report to your care team as soon as possible:

    • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
    • CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, difficulty staying awake
    • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
    • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision

    Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

    • Constipation
    • Dizziness
    • Drowsiness
    • Dry mouth
    • Headache
    • Nausea
    • Vomiting
    This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Where should I keep my medication?

    Keep out of the reach of children and pets. This medication can be abused. Keep it in a safe place to protect it from theft. Do not share it with anyone. It is only for you. Selling or giving away this medication is dangerous and against the law.

    Store at 25 degrees C (77 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.

    This medication may cause harm and death if it is taken by other adults, children, or pets. It is important to get rid of the medication as soon as you no longer need it, or it is expired. You can do this in two ways:

    • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
    • If you cannot return the medication, flush it down the toilet.
    NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

    What should I tell my care team before I take this medication?

    They need to know if you have any of these conditions:

    • Brain tumor
    • Frequently drink alcohol
    • Head injury
    • Heart disease
    • History of pancreatitis
    • Kidney disease
    • Liver disease
    • Low adrenal gland function
    • Lung or breathing disease, such as asthma
    • Seizures
    • Stomach or intestine problems
    • Substance use disorder
    • Taken an MAOI such as Marplan, Nardil, or Parnate in the last 14 days
    • An unusual or allergic reaction to oxycodone, other medications, foods, dyes, or preservatives
    • Pregnant or trying to get pregnant
    • Breastfeeding

    What may interact with this medication?

    Do not take this medication with any of the following:

    • Safinamide

    This medication may interact with the following:

    • Alcohol
    • Antihistamines for allergy, cough, and cold
    • Atropine
    • Certain antivirals for HIV or hepatitis
    • Certain antibiotics, such as clarithromycin, erythromycin, linezolid, rifampin
    • Certain medications for anxiety or sleep
    • Certain medications for bladder problems, such as oxybutynin, tolterodine
    • Certain medications for depression, such as amitriptyline, fluoxetine, sertraline
    • Certain medications for fungal infections, such as ketoconazole, itraconazole, posaconazole
    • Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
    • Certain medications for nausea or vomiting, such as dolasetron, granisetron, ondansetron, palonosetron
    • Certain medications for Parkinson disease, such as benztropine, trihexyphenidyl
    • Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin, primidone
    • Certain medications for stomach problems, such as dicyclomine, hyoscyamine
    • Certain medications for travel sickness, such as scopolamine
    • Diuretics
    • General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol
    • Ipratropium
    • MAOIs, such as Marplan, Nardil, and Parnate
    • Medications that relax muscles
    • Methylene blue
    • Other opioid medications for pain or cough
    • Phenothiazines, such as chlorpromazine, mesoridazine, prochlorperazine, thioridazine
    This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

    What if I miss a dose?

    If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

    What should I watch for while using this medication?

    Tell your care team if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to this medication. Tolerance means that you will need a higher dose of the medication for pain relief. Tolerance is normal and is expected if you take this medication for a long time.

    Taking this medication with other substances that cause drowsiness, such as alcohol, benzodiazepines, or other opioids can cause serious side effects. Give your care team a list of all medications you use. They will tell you how much medication to take. Do not take more medication than directed. Call emergency services if you have problems breathing or staying awake.

    Long term use of this medication may cause your brain and body to depend on it. This can happen even when used as directed by your care team. You and your care team will work together to determine how long you will need to take this medication. If your care team wants you to stop this medication, the dose will be slowly lowered over time to reduce the risk of side effects.

    Naloxone is an emergency medication used for an opioid overdose. An overdose can happen if you take too much of an opioid. It can also happen if an opioid is taken with some other medications or substances such as alcohol. Know the symptoms of an overdose, such as trouble breathing, unusually tired or sleepy, or not being able to respond or wake up. Make sure to tell caregivers and close contacts where your naloxone is stored. Make sure they know how to use it. After naloxone is given, the person giving it must call emergency services. Naloxone is a temporary treatment. Repeat doses may be needed.

    This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

    This medication will cause constipation. If you do not have a bowel movement for 3 days, call your care team.

    Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

    Talk to your care team if you may be pregnant. Prolonged use of this medication during pregnancy can cause temporary withdrawal in a newborn.

    Talk to your care team before breastfeeding. Changes to your treatment plan may be needed. If you breastfeed while taking this medication, seek medical care right away if you notice the child has slow or noisy breathing, is unusually sleepy or not able to wake up, or is limp.

    Long-term use of this medication may cause infertility. Talk to your care team if you are concerned about your fertility.

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