Clomiphene Tablets

CLOMIPHENE (KLOE mi feen) treats irregular or absent ovulation in people trying to get pregnant. It works by helping your body release an egg (ovulation), which increases the chance of pregnancy.

Take this medication by mouth with a glass of water. Take it as directed on the prescription label. Take exactly as directed for the exact number of days prescribed. This medication is usually taken for a 5-day period, but the length of treatment may be adjusted. Your care team will give you a start date for this medication and will give you instructions on proper use. Do not take your medication more often than directed.

Talk to your care team about the use of this medication in children. Special care may be needed.

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Change in vision
• Ovarian hyperstimulation syndrome—stomach or pelvic pain, bloating, nausea, vomiting, diarrhea, weight gain
• Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Breast pain or tenderness
• Headache
• Hot flashes
• Irregular menstrual cycles or spotting

Keep out of the reach of children and pets.

Store between 15 and 30 degrees C (59 and 86 degrees F). Protect from heat, light, and moisture. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

They need to know if you have any of these conditions:

• Adrenal gland disease
• Blood vessel disease or blood clots
• Cyst on the ovary
• Endometriosis
• Liver disease
• Ovarian cancer
• Pituitary gland disease
• Vaginal bleeding that has not been evaluated
• An unusual or allergic reaction to clomiphene, other medications, foods, dyes, or preservatives
• Pregnant (should not be used if you are already pregnant)
• Breastfeeding

• Herbal or dietary supplements, such as blue cohosh, black cohosh, chasteberry, or DHEA
• Prasterone

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Make sure you understand how and when to use this medication. You need to know when you are ovulating and when to have sexual intercourse. This will increase the chance of a pregnancy.

Visit your care team for regular checks on your progress. You may need tests to check the hormone levels in your blood, or you may have to use home-urine tests to check for ovulation. Try to keep any appointments.

Compared to other fertility treatments, this medication does not greatly increase your chances of having multiple babies. An increased chance of having twins may occur in roughly 5 out of every 100 women who take this medication.

Stop taking this medication at once and contact your care team if you think you are pregnant.

This medication is not for long-term use. Most women that benefit from this medication do so within the first three cycles (months). Your care team will monitor your condition. This medication is usually used for a total of 6 cycles of treatment.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Drinking alcoholic beverages or smoking tobacco may decrease your chance of becoming pregnant. Limit or stop alcohol and tobacco use during your fertility treatments.