Dinoprostone Vaginal Insert

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    Dinoprostone Vaginal Insert

    What is this medication?

    DINOPROSTONE (dye noe PROST one) relaxes and widens the cervix. It works by helping the cervix soften, thin, and open (dilate).

    This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

    How should I use this medication?

    This medication is inserted into the vagina in a hospital or clinic setting. Remain lying down for 2 hours after it is inserted. Your care team will remove the insert after it has been in place for 12 hours or after active labor begins.

    Talk to your care team about the use of this medication in children. Special care may be needed.

    Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

    What side effects may I notice from receiving this medication?

    Side effects that you should report to your care team as soon as possible:

    • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
    • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
    • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
    • Excessive, frequent uterine contractions
    • Shortness of breath or trouble breathing, dizziness, feeling faint or lightheaded, fast or irregular heartbeat

    Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

    • Back pain
    • Diarrhea
    • Fever
    • Nausea
    • Stomach pain
    This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Where should I keep my medication?

    This medication is given in a hospital or clinic and will not be stored at home.

    NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

    What should I tell my care team before I take this medication?

    They need to know if you have any of the following conditions:

    • Active genital, vaginal, uterine, or pelvic infection
    • Anemia
    • Glaucoma
    • Heart disease
    • High blood pressure
    • Kidney disease
    • Liver disease
    • Lung or breathing disease, such as asthma
    • Placenta previa
    • Previous pregnancy with difficult labor, traumatic delivery, or cesarean section
    • Previous surgery to the uterus
    • Seizure disorder
    • Six or more previous pregnancies
    • Uterine rupture or scars
    • Vaginal bleeding
    • An unusual or allergic reaction to dinoprostone, prostaglandins, other medications, foods, dyes, or preservatives
    • Breast-feeding

    What may interact with this medication?

    • Oxytocin
    This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

    What if I miss a dose?

    This does not apply.

    What should I watch for while using this medication?

    You will be closely monitored while you receive this medication.

    Contact your care team immediately if you get signs and symptoms of infection or other complications, such as pelvic or lower abdominal pain, an unpleasant vaginal discharge, fever, chills, or increase in vaginal bleeding several days after treatment.

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