English

ElsevierDrugInformation

Drug Patient Education

Learn more about Elsevier’s Drug Patient Education today! Empower and engage your patients to use medication safely.

Jan.13.2023

Sacubitril, Valsartan Oral tablet

What is this medication?

SACUBITRIL; VALSARTAN (sak UE bi tril; val SAR tan) treats heart failure. It works by relaxing blood vessels, which decreases the amount of work the heart has to do. It also helps your kidneys remove more fluid and salt from your blood through the urine. It is a combination of a neprilysin inhibitor and an ARB.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 1 year for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • High potassium level—muscle weakness, fast or irregular heartbeat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Cough
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Diabetes and take a medication that contains aliskiren
  • High levels of potassium in the blood
  • Kidney disease
  • Liver disease
  • Low blood pressure
  • An unusual or allergic reaction to sacubitril, valsartan, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Aliskiren if you have diabetes
  • Angiotensin-converting enzyme (ACE) inhibitors, such as benazepril, captopril, enalapril, fosinopril, lisinopril, or ramipril
  • Tranylcypromine

This medication may also interact with the following:

  • Angiotensin II receptor blockers (ARBs), such as azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, or valsartan
  • Celecoxib
  • Lithium
  • NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
  • Potassium-sparing diuretics, such as amiloride, spironolactone, and triamterene
  • Potassium supplements
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Avoid salt substitutes unless you are told otherwise by your care team.

;