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Follow instructions for SARS-COV-2 vaccine administration provided on Elsevier’s Vaccination Hub undefinedhttps://elsevier.health/en-US/preview/sars-cov2-vaccine" target="_blank">https://elsevier.health/en-US/preview/sars-cov2-vaccine or Clinical Key for Nursing https://www.clinicalkey.com/nursing/#!/content/drug_monograph/6-s2.0-5295.
Intramuscular (IM) injections have been associated with adverse reactions and pain. This route of medication injection is used as a last resort. Consider contacting the practitioner for an alternative, preferred route of medication administration.
Take steps to eliminate interruptions and distractions during medication preparation.
The IM injection route deposits medication into deep muscle tissue, which has a rich blood supply, allowing medication to be absorbed faster than it would be by the subcutaneous route. This rich blood supply, however, increases the risk for injecting medication directly into blood vessels. Any factor that interferes with local tissue blood flow affects the rate and extent of drug absorption.
An IM injection may require a long, large-gauge needle to penetrate deep muscle tissue.2 The appropriate needle length is determined by the patient’s size, age, and the amount of adipose tissue in the chosen injection site (Table 1).2,7 The needle must be long enough to reach the muscle tissue but not too long to present the risk of hitting underlying neurovascular structures or bone.2
IM injections should be administered so that the needle is perpendicular to the patient’s body or as close to a 90-degree angle as possible (Figure 1).2 IM injection sites should also be rotated to decrease the risk for hypertrophy. When possible, IM injections should be avoided in muscles that are emaciated or atrophied because these muscles absorb medication poorly.5
Aspiration before injection and slow injection of the medication are not supported by research for vaccine administration.2 For all other medications, there is no evidence to either support or abandon the practice of aspiration before administration. More research is needed to investigate the practice of aspiration before administering an IM injection with medications other than vaccines.9 The vastus lateralis and deltoid muscles are the only two sites recommended for vaccine administration because these sites do not contain large vessels that are within reach of the needle.2,5 The recommended route and site for each vaccine are included in the manufacturer’s instructions for use.2
Muscle tissue is less sensitive than subcutaneous tissue to irritating and viscous medications. Small muscles absorb small volumes. For a well-developed adult, no more than 3 ml of medication should be administered in a single IM injection because the muscle tissue does not absorb it well in larger volumes.5,8 For smaller adults or those with less muscle mass, the volume injected may need to be adjusted. There may be exceptions for specific medications. Refer to the organization’s formulary.
The Z-track method, in which the skin is pulled laterally before injection, prevents medication leakage into subcutaneous tissue, seals medication in the muscle, and minimizes irritation. This method can be used, provided that the overlying tissue can be displaced. To use the Z-track method in an adult, the appropriate-size needle is attached to the syringe, and an IM site is selected. After cleansing the site, the overlying skin and subcutaneous tissues are pulled to the side with the ulnar side of the nondominant hand. The skin is held in this position until the injection has been administered. The needle is injected deep into the muscle and the medication is injected slowly. After the needle is withdrawn, the skin is released. The displacement of the skin and muscle layer closes off the needle track when the skin is released (Figure 2).5
For IM injections, the nurse selects a site that is free of pain, infection, necrosis, bruising, and abrasions. The location of underlying bones, nerves, and blood vessels and the volume of medication to be administered are also considered. Because of the sciatic nerve location, the dorsogluteal muscle is not recommended as an injection site. If a needle hits the sciatic nerve, the patient may experience partial or permanent paralysis of the leg.5,8 The rectus femoris is no longer considered a safe injection site because of the risk of damage to the descending branch of the lateral circumflex femoral artery and the muscle branch of the femoral nerve to the vastus lateralis.6
The ventrogluteal site involves the gluteus medius and minimus muscles and is a safe injection site for adults.5 This site provides the greatest thickness of gluteal muscle, is free of penetrating nerves and blood vessels, and has a narrower layer of fat. The ventrogluteal muscle is the preferred and safest site for all adults, children, and infants for medications with larger volumes that may be more viscous and irritating.5,8 The ventrogluteal site should be used with caution in infants.1 It is recommended that only an experienced pediatric health care team member use this site.
To locate the ventrogluteal site, the heel of the hand is placed over the greater trochanter of the patient’s hip with the wrist almost perpendicular to the femur. The right hand is used for the left hip, and the left hand for the right hip. The thumb is pointed toward the patient’s groin, with the index finger pointing to the anterior superior iliac spine, and the middle finger is extended back along the iliac crest toward the buttock. The index finger, the middle finger, and the iliac crest form a V-shaped triangle. The injection site is the center of the triangle (Figure 3). To relax this site, the patient lies on the side or back, flexing the knee and hip.
The vastus lateralis muscle is another injection site used in adults. This muscle is thick and well developed and is located on the anterior lateral aspect of the thigh. It extends, in an adult, from a handbreadth above the knee to a handbreadth below the greater trochanter of the femur (Figure 4). The middle third of the muscle is used for injection. To help relax the muscle, the patient is asked to lie supine, with the knee slightly flexed and foot externally rotated, or to assume a sitting position.
Although the deltoid site is easily accessible, this muscle is not well developed in many adults. There is potential for injury because the axillary, radial, brachial, and ulnar nerves and the brachial artery lie within the upper arm under the triceps and along the humerus (Figure 5). This site is used for small medication volumes (2 ml or less)5,8 and for administration of routine immunizations in adults.2
The deltoid muscle is located by fully exposing the patient’s upper arm and shoulder and asking the patient to relax the arm at the side or by supporting the patient’s arm and flexing the elbow. Next, the lower edge of the acromion process, which forms the base of a triangle in line with the midpoint of the lateral aspect of the upper arm, is palpated. The nurse measures 2 to 3 finger widths3 down from the acromion process and visualizes a triangle, with the base at the acromion process and the apex pointing toward the elbow. The injection site is found in the center of the triangle (Figure 5).
To avoid shoulder injury related to vaccine administration, the nurse should always sit to inject into the arm of a seated patient to ensure that the angle of the needle is correct. If the patient’s shirt cannot be removed, the sleeve should be rolled up so that landmarks can be visualized and used appropriately.3
Rarely, an adverse reaction occurs after immunizations. Reactions may include anaphylaxis, anaphylactic shock, and neurologic deficits.10 Vaccine adverse event reporting is monitored by the Centers for Disease Control and Prevention.
If the patient, family, and caregivers express concern regarding the accuracy of a medication, the medication should not be given. The concern should be explored, the practitioner notified, and the order verified.
Do not use medication that is cloudy or precipitated unless such is indicated by its manufacturer as being safe.
Rationale: Injection sites should be free of abnormalities that interfere with drug absorption (e.g., bruising, signs associated with infection).
Rationale: Sites used repeatedly become hardened from lipohypertrophy (increased growth in fatty tissue).
Rationale: A comfortable position reduces strain on the muscle and minimizes injection discomfort.
Rationale: Injection into the correct anatomic site prevents injury to nerves, bone, and blood vessels.
The dorsogluteal site is not recommended because of proximity to the sciatic nerve.5
Rationale: A vapocoolant spray decreases pain at the injection site.
Rationale: The swab or gauze remains readily accessible for use when withdrawing the needle.
Rationale: Pulling the cap straight off prevents the needle from touching the sides of the cap, thus preventing contamination.
Rationale: A quick, smooth injection requires proper manipulation of the syringe parts.
Rationale: The Z-track technique creates a zigzag path through tissues that seals the needle track to avoid tracking medication. A quick, dart-like injection reduces discomfort. Z-track injections may be used for all IM injections.5,8
Rationale: Smooth manipulation of the syringe reduces discomfort from needle movement. Skin remains pulled until after medication is injected to ensure Z-track administration.
Rationale: Grasping the muscle body helps to ensure that the medication reaches the muscle mass.
Rationale: Aspiration of blood into the syringe indicates possible placement into a vein.
Rationale: There is no definitive research to recommend eliminating aspiration other than for vaccination and toxoids.5,8
Rationale: Massage damages underlying tissue.
Rationale: Discarding the uncapped needle helps prevent injury to the patient and staff. Recapping needles increases the risk for a needlestick injury.7
Report profuse bleeding, hematoma, loss of function, and signs and symptoms of infection.
Report rash, seizures, and difficulty breathing.
Centers for Disease Control and Prevention (CDC). (2018). Vaccine administration. Retrieved October 13, 2022, from https://www.cdc.gov/vaccines/hcp/admin/admin-protocols.html
Institute for Safe Medication Practices (ISMP). (2012). Side tracks on the safety express. Interruptions lead to errors and unfinished…Wait, what was I doing? Retrieved October 13, 2022, from http://www.ismp.org/Newsletters/acutecare/showarticle.aspx?id=37 (classic reference*)
Kroger, A.T., Bahta, L., Hunter, P. (2022). Vaccine recommendations and guidelines of the ACIP: General best practice guidelines for immunization. Retrieved October 13, 2022, from https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/index.html
U.S. Food and Drug Administration (FDA). (2021). Safely using sharps (needles and syringes) at home, at work and on travel. Retrieved October 13, 2022, from http://www.fda.gov/medicaldevices/productsandmedicalprocedures/homehealthandconsumer/consumerproducts/sharps/default.htm
*In these skills, a “classic” reference is a widely cited, standard work of established excellence that significantly affects current practice and may also represent the foundational research for practice.
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